体位改变对Beagle犬心脏自主神经控制的影响
作者:
作者简介:

潘永明(1979-),男,助理研究员,研究方向:实验动物与动物实验,E-mail:pym918@126.com。

基金项目:

浙江省实验动物科技计划项目(2009F80018);浙江省卫生高层次创新人才培养工程项目。


Effect of Postural Changes on Autonomic Nervous Control of Heart in Beagle Dogs
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    摘要:

    目的观察体位改变对Beagle犬心脏自主神经控制的影响。方法利用大动物无创生理遥测技术,监测清醒活动状态下雌性Beagle犬在静态姿势(lying、standing、sitting、hanging)和运动(walking)姿势下的心电图(ECG),并用HRV功率谱分析其自主神经功能。结果在静态姿势下,Beagle犬RR间期(RRI)、RR 间期的标准差SDNN(SDNN)、相邻 RR 间期差值平方和的均方根RMSSD(RMSSD)、相邻 R-R 间期差值>50 ms 的窦性个数占心搏总数的百分比pNNabs (50)(pNNabs (50))、TP总功率(TP)、VLF极低频功率(VLF)、标准化高频功率(HF norm)均明显高于运动状态(P<0.05, P<0.01),而心率(HR)、标准化低频功率(LFnorm)和低频功率/高频功率(LF/HF)平衡指数则明显低于运动状态(P<0.05 ,P<0.01)。结论不同体位姿势在静息状态下以迷走神经活动兴奋为主,相反,在运动状态下以交感神经活动兴奋为主;体位姿势改变能引起心率的变化,必然影响心脏自主神经控制能力,其主要取决于迷走神经活动强弱有关,且导致LF/HF均衡性的破坏。

    Abstract:

    ObjectiveThe aim of this study was to observe the effect of postural changes on autonomic nervous control of heart in Beagle dogs. Methods Electrocardiogram (ECG) was recorded in static posture (lying, standing, sitting and hanging) and moving posture (walking) from conscious and unrestrained female Beagle dogs using a non-invasive telemetry system, and the autonomic nervous function was investigated by power spectral analysis of heart rate variability (HRV). ResultsIn static postures, the RR interval, SDNN, RMSSD, pNNabs (50), total power (TP), very low frequency (VLF) power and normalized high frequency (HF) power were significantly higher than those in moving posture (P<0.05, P<0.01), while the heart rate, normalized LF and the LF to HF ratio were significantly lowered (P<0.05, P<0.01). Conclusions The parasympathetic nervous activity is dominant in static state of different postures, while sympathetic nervous activity is dominant in moving state. Postural changes can influence the heart rate and inevitably affect the cardiac autonomic nervous control. It depends on the intensity of the vagus nerve activity, and leads to the disturbance of LF/HF balance. 

    参考文献
    [1] 潘永明, 陈亮, 何欢, 等.无创遥测技术观察运输应激对Beagle犬部分生理指标的影响 [J].中国比较医学杂志, 1,1(4):56-61.
    [2] 潘永明, 陈亮, 何欢, 等.心率变异性评估运输应激对Beagle犬自主神经功能的影响 [J].中国实验动物学报, 1,9(1):69-73.
    [3] King T, Hemsworth PH, Coleman GJ.Fear of novel and startling stimuli in domestic dogs [J].Appl Anim Behav.Sci.3,2:45-64.
    [4] Langbein J, Nürnberg, G, Manteuffel G.Visual discrimination learning in dwarf goats and associated changes in heart rate and heart rate variability [J].Physiol.Behav.2004., 2,1-609.
    [5] Carnethon MR, Liao D, Evans GW, et al.Correlates of the shift in heart rate variability with an active postural change in a healthy population sample:the Atherosclerosis Risk In Communities study [J].Am Heart J.2,3:808-813.
    [6] Vuksanovic V, Gal V, Kalanj J, et al.Effect of posture on heart rate variability spectral measures in children and young adults with heart disease [J].Int J Cardiol.5,1:273-278.
    [7] Kamath MV, Fallen EL, Power spectral analysis of heart rate variability:a noninvasive signature of cardiac autonomic function [J].Crit Rev Biomed Eng, 3,1:245-311.
    [8] Martinmaki K, Rusko H, Saalasti S, et al.Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts:a pharmacological blocking study [J].AJP-Heart, 6,0(6):2582-2589.
    [9] Pagani M, Lombardi F, Guzzetti S,et al.Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog [J].Circ Res.6,9:178-193.
    [10] Akselrod S, Gordon D, Ubel F, et al.Power spectral analysis of heart rate fluctuation:a quantitative probe of beat-to beat cardiovascular control [J].Science, 1,3(4504):220-222.
    [11] Harada T, Abe J, Shiotani M, et al.Effect of autonomic nervous function on QT interval in dogs [J].J Toxicol Sci, 5,0(3):229-237.
    [12] 张再青, 康汉丽, 李法升.孕妇体位改变对胎儿脐动脉血流速度影响的研究 [J].现代医院, 0,0(7):11-12.
    [13] 郭义红.头位难产中体位改变配合徒手矫正胎方位的临床价值 [J].当代医学, 0,6(21):31-32.
    [14] 张志利, 李艳.体位改变和气腹对妇科腔镜手术气管插管深度的影响 [J].河北医药, 7,9(2):181.
    [15] 黄锦华.人体位改变对肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)影响的初步探讨 [J].海南医学, 4,5(3):81-83.
    [16] Kuwahara M, Suzuki A., Tsutsumi H., et al.Power spectral analysis of heart rate variability for assessment of diurnal variation of autonomic nervous activity in miniature swine [J].Lab Anim Sci., 9,9(2):202-208.
    [17] Kuwahara M, Hashimoto S, Tsubone H, et al.Power spectral analysis of heart rate variability in spontaneously hypertensive rats [J].Jpn Heart J.4,5:367-368.
    [18] 应乐安, 王成焘, 沈仲元, 等.体位变化对人体心率的即刻变化研究 [J].实用心电图杂志, 8,7(4):248-250.
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潘永明,陈亮,何欢,徐孝平,陈民利.体位改变对Beagle犬心脏自主神经控制的影响[J].中国比较医学杂志,2012,(2):47~51.

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