| 刘晓蕾,姜树原,邵 国,谢雅彬,贾小娥,谢 伟.NR2B 亚基磷酸化在缺血 / 低氧神经保护中的作用[J].中国比较医学杂志,2023,33(1):125~129. |
| NR2B 亚基磷酸化在缺血 / 低氧神经保护中的作用 |
| Effects of N-methyl-D-aspartate receptor NR2B phosphorylation on ischemic / hypoxic neuroprotection |
| 投稿时间：2022-03-05 |
| DOI：10. 3969 / j.issn.1671-7856. 2023. 01. 016 |
| 中文关键词: NMDA NR2B 缺血/ 低氧 磷酸化 神经保护 |
| 英文关键词:NMDA NR2B ischemic / hypoxic phosphorylation neuroprotection |
| 基金项目: |
| 作者 | 单位 | | 刘晓蕾 | 1.包头医学院药学院,内蒙古 包头 014040
2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 014040
3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220 | | 姜树原 | 1.包头医学院药学院,内蒙古 包头 014040
2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 014040
3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220 | | 邵 国 | 2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 014040
3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220
4.深圳市龙岗区第三人民医院转化医学中心检验科,广东 深圳 518112 | | 谢雅彬 | 内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 014040 | | 贾小娥 | 内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 014040 | | 谢 伟 | 2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 014040
3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220 |
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| Author Name | Affiliation | | LIU Xiaolei | 1. School of Pharmacy, Baotou Medical College, Baotou 014040, China. 2. Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou 014040. 3. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand. | | JIANG Shuyuan | 1. School of Pharmacy, Baotou Medical College, Baotou 014040, China. 2. Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou 014040. 3. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand. | | SHAO Guo | 2. Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou 014040. 3. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand. 4. Center for Translational Medicine and Department of Laboratory Medicine, the Third People’s Hospital of Longgang District Shenzhen, Shenzhen 518112 | | XIE Yabin | Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou 014040 | | JIA Xiaoe | Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou 014040 | | XIE Wei | 2. Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou 014040. 3. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand. |
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| 中文摘要: |
| N-甲基-D-天冬氨酸(NMDA)受体在神经系统功能中起着关键作用。 NR2B 亚基是 NMDA 受体的调节亚单位,在低氧/ 缺血神经保护中有重要作用。 NR2B 磷酸化是调节 NMDA 受体功能的重要机制,通过磷酸化的变化在缺血/ 低氧神经保护中发挥重要作用。 本文综述了 NMDA 受体 NR2B 亚基的结构、功能、磷酸化、信号通路与缺血/ 低氧神经保护的关系,为以 NR2B 亚基为靶点进行低氧/ 缺血脑疾病的防治工作提供思路。 |
| 英文摘要: |
| N-methyl-D-aspartate (NMDA) receptor plays an important role in the function of the nervous system. The NR2B subunit is the regulatory subunit of NMDA receptor, which is closely related to the neuroprotection of hypoxia / ischemia. Phosphorylation of NR2B is considered to be an important mechanism to regulate the NMDA receptor function and plays an important role in ischemic / hypoxic neuroprotection through the change in phosphorylation. This review discusses the development of the NR2B subunit of NMDA receptor and the relationships between the structure, function, phosphorylation, signaling pathway and ischemic / hypoxic neuroprotection to provide a theoretical foundation to prevent and treat hypoxic / ischemic brain diseases with NR2B subunit as the target. |
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