| 冯 博,刘姿宇,李 月,刘立琨,岳丽玲.岩藻糖基化与肿瘤多药耐药[J].中国比较医学杂志,2023,33(1):113~118. |
| 岩藻糖基化与肿瘤多药耐药 |
| Fucosylation and multidrug resistance of tumors |
| 投稿时间：2022-04-21 |
| DOI：10. 3969 / j.issn.1671-7856. 2023. 01. 014 |
| 中文关键词: 岩藻糖基化 岩藻糖基化抑制剂 多药耐药 恶性肿瘤 |
| 英文关键词:fucosylation fucosylation inhibitors multidrug resistance malignant tumor |
| 基金项目: |
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| Author Name | Affiliation | | FENG Bo | College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China | | LIU Ziyu | College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China | | LI Yue | College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China | | LIU Likun | Research Institute of Medical Sciences and Pharmacy, Qiqihar Medical University, Qiqihar 161006 | | YUE Liling | Research Institute of Medical Sciences and Pharmacy, Qiqihar Medical University, Qiqihar 161006 |
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| 中文摘要: |
| 岩藻糖基化是最常见的糖基化修饰之一,与癌症的发生发展及预后密切相关。有研究报道,岩藻糖基转移酶的变化与肿瘤多药耐药具有一定的相关性,肿瘤细胞多药耐药是影响临床化疗效果的最重要因素之一,常常导致治疗效果不佳、患者预后不良等。本文重点介绍了岩藻糖基转移酶家族成员及其催化的岩藻糖基化修饰与肿瘤多药耐药的相关性,简述了岩藻糖基化抑制剂对肿瘤的治疗作用,提出岩藻糖类似物作为岩藻糖基化抑制剂有可能成为逆转肿瘤多药耐药的潜在药物,为将岩藻糖基化修饰作为临床肿瘤耐药逆转和增敏的药物靶点提供依据。 |
| 英文摘要: |
| Fucosylation is one of the most common glycosylation modifications that is closely related to the occurrence, development, and prognosis of cancer. A change in fucosyltransferase correlations with tumor multidrug resistance has been reported. Multidrug resistance of tumor cells is a major factor affecting chemotherapy efficacy, which often leads to a poor therapeutic effect and prognosis. This review focuses on the relationship between fucosyltransferase family members and their catalytic fucosylation modification and tumor multidrug resistance, briefly summarizes the therapeutic effect of fucosylation inhibitors on tumors, and describes fucosylation analogues as fucosylation inhibitors that may be potential drugs to reverse tumor multidrug resistance. This article provides a basis for fucosylation modification as a drug target to reverse and sensitize tumor drug resistance. |
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