阻塞性睡眠呼吸暂停综合征与炎症相关性研究进展
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1.南昌大学基础医学院病原生物学实验中心,南昌 330006;2.南昌大学第二临床医学院,南昌 330006;3.南昌大学公共卫生学院,南昌 330006;4.南昌大学抚州医学院生理学教研室,江西 抚州 344000;5.南昌大学抚州医学院慢性病研究重点实验室,江西 抚州 344000

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R-33

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Research progress on the correlation between obstructive sleep apnea syndrome and inflammation
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1.Pathogen Biology Experimental Center, College of Medicine, Nanchang University, Nanchang 330006, China. 2. the Second Clinical Medical College of Nanchang University, Nanchang 330006. 3. Public Health of Nanchang University, Nanchang 330006.4. Department of Physiology Fuzhou Medical College, Nanchang University, Fuzhou 344000. 5. Key Research Laboratory of Chronic Disease, Fuzhou Medical College, Nanchang University, Fuzhou 344000

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    摘要:

    阻塞性睡眠呼吸暂停综合征( obstructive sleep apnea syndrome, OSAS)作为一种睡眠呼吸紊乱的慢性疾病,以睡眠时出现反复上气道的部分或完全塌陷,临床表现为睡眠片段化、严重打鼾和白天嗜睡。 由于其发病率较高,常常影响患者生活质量和生存率,正被越来越多的人所重视。最近许多研究表明,OSAS 的特征是炎症反应,炎症相关因子水平的变化也提示 OSAS 合并心血管疾病的可能性。共同的危险因素的存在,以及一些共同的致病途径,证明了 OSAS 与炎症之间的潜在关系。因此,本研究的目的是综述 OSAS 与炎症相关性研究进展,有利于我们更好地了解 OSAS 的发病机制。

    Abstract:

    Obstructive sleep apnea syndrome ( OSAS ) is a chronic disease of sleep-disordered breathing characterized by repeated collapse of part or all of the upper respiratory tract during sleep. Its clinical manifestations include fragmentation of sleeping, severe snoring, and excessive daytime sleepiness. Because of its high incidence and ability to affect the quality of life and survival rate of patients, increasingly more people have been attaching clinical importance to OSAS. Many recent studies have shown that OSAS is characterized by inflammation, and changes in the levels of inflammatory-related factors suggest the possibility that OSAS is complicated by cardiovascular disease. The potential relationship between OSAS and inflammation is demonstrated by the presence of common risk factors between the two conditions as well as several common pathogenicity approaches. Therefore, this study was performed to summarize the research progress on the correlation between OSAS and inflammation and thus increase our understanding of the pathogenesis of OSAS.

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赵 莎,雷 璇,熊佳敏,杨树龙,洪芬芳.阻塞性睡眠呼吸暂停综合征与炎症相关性研究进展[J].中国比较医学杂志,2022,32(11):101~106.

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  • 收稿日期:2022-02-11
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  • 在线发布日期: 2023-01-18
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自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
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