Ischemia is a kind of localized ischemic necrosis or softening caused by infarction of tissues and organs or blood supply disturbance, which often occurs in the liver, kidney, brain, and other organs. In the early stage of restoring blood supply, it often causes ischemia-reperfusion injury. Oxidative stress is a major causes of ischemia- reperfusion injury. Studies have confirmed that ischemia-reperfusion leads to the production of reactive oxygen species, which causes organ injury and dysfunction. This review summarizes the research progress of ischemia-reperfusion oxidative injury in recent years from the perspective of oxidative stress and analyzes the effect of this injury on various tissues and organs. It aims to further reveal the mechanism of oxidative injury caused by ischemia-reperfusion and provide ideas for the prevention and treatment of related diseases.