Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck, and its incidence is increasing yearly. Glucose metabolism reprogramming is the most representative metabolic feature of tumors, which has unique characteristics of energy metabolism. In the case of sufficient oxygen, tumor cells prefer glycolysis over highly productive mitochondrial oxidative phosphorylation. Current studies have shown that non-coding RNA (ncRNA) directly targets glucose transport protein and key enzyme to change glucose metabolism or indirectly changes glucose metabolism by regulating cancer-related signaling pathways during the occurrence and development of OSCC. This article reviews the mechanism of ncRNA in the regulation of aerobic glycolysis in OSCC.