Abstract:Local allergic rhinitis (LAR) is a local allergic disease of nasal mucosa that is different from allergic rhinitis (allergic rhinitis, AR). Although the prevalence of LAR is high, research and understanding of LAR is still in its infancy. Animal models are a necessary means to deepen understanding of the pathogenesis, pathophysiology and immunology of LAR. Animal models of AR are relatively well established. Because there are some similarities between AR and LAR, despite each disease having their own characteristics, this study has reviewed the selection of animal models for LAR research, including allergen selection, the modeling process and animal model evaluation, in comparison with the AR animal model.