在与变应性鼻炎比较中探索局部变应性鼻炎模型的建立
作者:
作者单位:

1.成都中医药大学附属医院耳鼻喉科,成都 610072;2.成都中医药大学,成都 610072

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R-33

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To explore the establishment of local allergic rhinitis model in comparison with allergic rhinitis
Author:
Affiliation:

1.Department of Otorhinolaryngology, the Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China. 2. Chengdu University of Traditional Chinese Medicine, Chengdu 610072

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    摘要:

    局部变应性鼻炎(local allergic rhinitis,LAR)是有别于变应性鼻炎( allergic rhinitis,AR)的鼻黏膜局部变态反应性疾病。虽然 LAR 流行率总体呈高发趋势,但目前对其研究和认识尚处于起步阶段。 LAR 动物模型是深化 LAR 发病机制、病理生理学及免疫学研究的必要手段。 由于 LAR 与 AR 的发病机制既相似又各具特点,且 AR 动物建模方法相对较为成熟,故本文在与 AR 动物建模的联系与比较中,就 LAR 建模动物的选择、致敏原选择、建模流程、动物模型评价研究进展作一综述。

    Abstract:

    Local allergic rhinitis (LAR) is a local allergic disease of nasal mucosa that is different from allergic rhinitis (allergic rhinitis, AR). Although the prevalence of LAR is high, research and understanding of LAR is still in its infancy. Animal models are a necessary means to deepen understanding of the pathogenesis, pathophysiology and immunology of LAR. Animal models of AR are relatively well established. Because there are some similarities between AR and LAR, despite each disease having their own characteristics, this study has reviewed the selection of animal models for LAR research, including allergen selection, the modeling process and animal model evaluation, in comparison with the AR animal model.

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曹文灿,蒋明君,冯胜岚,敬 然,李林霜,李玖林,刘 洋,李昕蓉.在与变应性鼻炎比较中探索局部变应性鼻炎模型的建立[J].中国比较医学杂志,2021,31(12):103~107,114.

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  • 收稿日期:2020-12-08
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  • 在线发布日期: 2022-01-28
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