Transformational medicine is a bridge between basic disciplines and laboratory / clinical disciplines. At present, it is the major concept for cultivating complex medical talents at home and abroad. This paper expounds and discusses the process and effect of participating in an open animal experiment course of biochemistry and molecular biology at our university. It shows that the concept of transformational medicine is introduced into the open animal experiments of biochemistry and molecular biology, and the close connection between theoretical knowledge and experimental practice; this not only improves the interest in learning theoretical knowledge, but also cultivates and exercises scientific research thinking and hands-on ability.