烟碱对心肌梗死大鼠痛阈可塑性变化的影响及心脏保护作用
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1.佳木斯大学临床医学院 2016 级临床医学 7 班,黑龙江 佳木斯 154007; 2.佳木斯大学附属第一医院, 黑龙江 佳木斯 154007; 3.佳木斯大学基础医学院,黑龙江 佳木斯 154007

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R-33

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Effects of nicotine on pain threshold plastic changes and cardiac protection in myocardial infarction rats
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1.Class 7, Grade 2016 Clinical Medicine, Clinical School of Medicine, Jiamusi University, Jiamusi 154007, China. 2. The First Affiliated Hospital of Jiamusi University, Jiamusi 154007. 3. Basic Medical College of Jiamusi University, Jiamusi 154007

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    摘要:

    目的 观察心肌梗死大鼠痛阈的可塑性改变,探究烟碱对内脏痛的影响及对缺血心肌是否有保护作用。 方法 选取 SPF级Sprague-Dawlay 健康雄性大鼠 30只,体重180~ 200 g,以随机数字原则分为假手术组、模型组、烟碱治疗组。各组大鼠均观察心电图(ECG)、痛阈(热痛阈 PWL、机械痛阈 PWT)、左心室内压幅度变化、心脏体重指数、肌酸激酶同工酶(CK-MB) 的改变。 结果 模型组较假手术组比,机械痛阈变小,热痛阈变大(P< 0. 05);而血浆 CK-MB 活性、心脏体重指数、左心室内压明显升高(P<0. 05)。烟碱治疗组较模型组比,机械痛阈变大,热痛阈变小;血浆CK-MB 活性、心脏体重指数、左心室内压明显降低 (P<0. 05),差异具有统计学意义。 结论 烟碱对心肌梗死大鼠的心肌缺血症状以及由于缺血造成的内脏疼痛均有一定的缓解作用,其作用机制可能和胆碱 能抗炎通路激活有关,从而起到改善大鼠疼痛和保护大鼠心脏的作用。

    Abstract:

    Objective To observe the plastic changes of pain threshold in myocardial infarction rats, and to investigate the effects of nicotine on visceral pain and whether it has protective effects on ischemic myocardium. Methods Thirty healthy male Sprague-Dawley rats weighing 180 to 200 g were selected and divided into a sham surgical group, model group, or nicotine treatment group at random. The changes of electrocardiogram (ECG), pain threshold ( thermal pain threshold PWL, mechanical pain threshold PWT), left ventricular pressure amplitude, cardiac body mass index, and creatine kinase isoenzyme (CK-MB) were observed in all groups of rats. Results Upon comparing the model group with the sham surgical group, the mechanical pain threshold decreased and the thermal pain threshold became larger in the former group (both P<0. 05), while the plasma CK-MB activity, cardiac body mass index, and left ventricular pressure significantly increased (all P<0. 05). In addition, when the nicotine treatment group was compared with the model group, the mechanical pain threshold increased in the former group, while the thermal pain threshold decreased, as did the plasma CK-MB activity, cardiac body mass index, and left ventricular pressure (all P<0. 05). Conclusions Nicotine can relieve myocardial ischemia symptoms and visceral pain caused by ischemia in rats with myocardial infarction. Its mechanism may be related to activation of the cholinergic anti-inflammatory pathway. Therefore, it can improve the pain and protect the heart of rats.

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薛晴,于海波,李晶,于海涛.烟碱对心肌梗死大鼠痛阈可塑性变化的影响及心脏保护作用[J].中国比较医学杂志,2020,30(1):17~20.

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  • 收稿日期:2019-08-31
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  • 在线发布日期: 2020-08-19
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