有氧运动联合丹皮酚PLGA 纳米粒对肥胖伴高脂血症大鼠的保护作用
作者:
作者单位:

(1.武汉民政职业学院康复医疗学院,武汉 430079; 2.湖北省中医院肥胖体重管理中心,武汉 430074)

作者简介:

通讯作者:

中图分类号:

R-33

基金项目:


Protective effect of aerobic exercise combined with paeonol poly(lactic-co-glycolic) acid nanoparticles on obese rats with hyperlipidemia
Author:
Affiliation:

(1.College of Rehabilitation Medicine, Wuhan Civil Administration College, Wuhan 430079, China.2. Obesity Weight Management Center, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430074)

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的 探讨有氧运动联合丹皮酚PLGA 纳米粒对肥胖伴高脂血症大鼠的血生化及脂代谢作用影响。方法 清洁级雄性SD 大鼠40 只,采用高脂饮食诱导8 周构建肥胖伴高脂血症模型,将模型大鼠随机分为模型对照组(Model),有氧运动组(MS),丹皮酚PLGA 纳米粒组(MP)和有氧运动联合丹皮酚PLGA 纳米粒组(SP),每组8 只,连续干预6 周并测量体重;干预结束后采用全自动血生化分析仪对大鼠血清中的总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白(HDL-C)的含量进行分析并计算肝脏系数;同时对血清中的脂蛋白酶(LPL)肝脂酶(HL)含量进行检测,并对腹部脂肪进行取样做HE 染色分析。结果 MS 组、MP 组和SP 组的体重、血生化参数、肝脏系数、脂蛋白酶和肝脂酶含量等指标与模型对照组相比均得到改善,且SP 干预组的效果最优,与模型对照组相比均具统计学差异( P <0. 01),而MS 与MP 相比,没有统计学差异。腹部脂肪病理学切片统计结果表明相同视野下SP干预组大鼠腹部脂肪细胞较小,数目最多。结论 有氧运动联合丹皮酚PLGA 纳米粒干预能够明显改善由高脂饮食诱导的肥胖伴脂质代谢紊乱,能够降低肝脏指数,有效调节脂质代谢缓解脂肪蓄积。

    Abstract:

    Objective To investigate the effects of aerobic exercise combined with paeonol poly(lactic-coglycolic) acid (PLGA) nanoparticles on blood biochemistry and lipid metabolism in obese rats with hyperlipidemia. Methods Male Sprague-Dawley rats were fed a high-fat diet to induce a model of obesity with hyperlipidemia. Model rats were randomly divided into the model control group, aerobic exercise group, paeonol PLGA nanoparticle group, and aerobic exercise combined with paeonol PLGA nanoparticle group (SP), with 8 rats per group. The intervention was continuous, and the body weights were measured weekly for 6 weeks. After the intervention, total cholesterol, triglycerides and highdensity lipoprotein were assayed using an automatic blood biochemistry analyzer, and then the liver coefficient was calculated. The serum lipoproteinase and hepatic lipase contents were detected, and the abdominal fat was sampled for pathological examination. Results The body weight, blood biochemical parameters, liver coefficient, lipoproteinase and hepatic lipase contents of the aerobic exercise group, paeonol PLGA nanoparticle group and SP groups were improved, compared with those of the model control group. The SP group was improved the most compared with the model control group, and the result were statistically significant ( P <0. 01). The result of the abdominal fat pathology for the same field of view showed that the SP group mice had the most small and numerous abdominal fat cells. Conclusions Aerobic exercise combined with paeonol PLGA nanoparticles can ameriortae the obeisity-acompanying high-fat diet-induced lipid metabolic disorder, reduce the liver indices, regulate lipid metabolism and alleviate fat accumulation in rats.

    参考文献
    相似文献
    引证文献
引用本文

刘静,肖明中.有氧运动联合丹皮酚PLGA 纳米粒对肥胖伴高脂血症大鼠的保护作用[J].中国比较医学杂志,2019,29(12):88~93.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2019-04-09
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2020-01-13
  • 出版日期:
自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
关闭