The choice of an appropriate mouse model of acne according to the experimental purpose is very important for the study of the pathogenesis of acne or the evaluation of the efficacy of anti-acne drugs. According to the principle of modeling, mouse models of acne were classified into three categories: Propionibacterium acne, chemical acne, and androgen-induced acne. Taking the classification of mouse acne models as its starting point, this paper summarizes the modeling method, the scope of their applications, and their advantages and disadvantages, to facilitate the selection of a suitable mouse model for acne research.