Abstract:3-methyladenine (3-MA) is a classic autophagy inhibitor that mainly inhibits autophagosome formationand development. In the nervous system, 3-MA plays an important role in central nervous system diseases, peripheralnervous system diseases, nerve injuries, and neurodegenerative diseases. However, the exact effect of 3-MA in nervoussystem diseases is controversial, and its application lacks systematic discussion. This paper reviews both the role of 3-MA innervous system diseases and the relevant research on this role, and to provide new ideas for further research.