血友病鼠模型的构建及研究进展
作者:
作者单位:

(1.华北理工大学,河北唐山063000;2.华北理工大学附属医院,河北唐山063000)

作者简介:

通讯作者:

中图分类号:

R-33

基金项目:


Construction and research progress of hemophilia mouse models
Author:
Affiliation:

(1. North China University of Science and Technology, Tangshan 063000, China. 2. The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000)

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    血友病是一种单基因遗传性疾病,主要发病机制为编码凝血因子的基因突变所导致凝血因子减少?临床表现为反复出血,严重时可危及生命,尚不能治愈?目前正在研究的基因治疗则具有治愈血友病的可能?在基因治疗的研究中,动物模型是必不可少的基础支持条件?血友病鼠模型因其自身特点,如便于运输,研究费用少于其它大型动物等,在众多动物模型中脱颖而出,成为血友病动物模型研究的热点?血友病鼠模型的构建经过20多年的历程,逐渐成熟?极大地促进了血友病基因治疗的发展,现就血友病鼠的构建及研究进展予以综述?

    Abstract:

    Hemophilia is a monogenic hereditary disease whose pathogenesis includes the reduction of coagulationfactors caused by mutations in genes encoding coagulation factors. The clinical manifestation of this disease is recurrentbleeding, which can be life-threatening in severe cases and cannot be cured. Currently, gene therapy might have thepotential to cure hemophilia. In gene therapy research, animal models are commonly used. The mouse hemophilia model isuseful because of its convenience for transportation and lower research costs when compared with other large animal models.It has become a hot spot for research using animal hemophilia models. After more than 20 years of development, technologyto generate a mouse hemophilia model has gradually matured. The aim of this paper is to summarize the research progress in generation of a mouse hemophilia model.

    参考文献
    相似文献
    引证文献
引用本文

李杰,闫振宇.血友病鼠模型的构建及研究进展[J].中国比较医学杂志,2019,29(6):141~146.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2018-11-27
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2019-07-16
  • 出版日期:
自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
关闭