Drug addiction is a serious public health problem worldwide for which there are no established therapeutic medications. Since the legalisation of cannabis and the approval of cannabidiol (CBD) by the US Food and Drug Administration, the therapeutic potential of CBD in the treatment of substance abuse has been widely explored. Numerous studies have shown that CBD exhibits therapeutic potential to reduce drug reward in animal models of addiction such as self-administration, conditioned positional preference, and intracranial self-stimulation.CBD can reduce withdrawal symptoms from substances such as amphetamines, opioids, cocaine, marijuana, alcohol, and nicotine.However, the mechanisms by which CBD modulates drug addiction are more complex and are currently understudied. Now, we review the studies related to CBD and addictive drugs with the aim of exploring the regulatory mechanisms of CBD in drug addiction and providing references for the related studies on substance abuse.