Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in childhood, which is called "spot toxin", "purpura wind" and "grape plague" in TCM. Modern medical research suggests that the disease is related to factors such as imbalance of cellular and humoral immunity, abnormal secretion of cytokines, disturbance of coagulation and fibrinolysis mechanism, but the exact pathogenesis is still unclear. The incidence of this disease increasing year by year, with a high recurrence rate and a high proportion of kidney damage, which seriously affects the physical and mental health of the[[基金项目] 国家自然科学基金（82374519,U2004107）；河南省青年科学基金项目（232300421309）；河南省中医药科学研究专项（20-21ZY2161） [作者简介] 苏杭（1988-），男，副主任医师，硕士研究生，研究方向：中医药防治小儿肾病及风湿免疫性疾病 Email：362504467@qq.com [通信作者] 任献青（1973-），男，教授，主任医师，博士研究生，研究方向：中医药防治小儿肾病及风湿免疫性疾病 Email：renxq723@163.com ] affected children and poses a great social risk. Numerous studies have shown the clinical efficacy of TCM in treating HSP, but its mechanism of action is not yet completely clear. In recent years, a large number of animal experiments have been carried out to study the efficacy mechanism of TCM with the establishment of animal models of HSP, but there is a lack of a more systematic and detailed reviews. Therefore, the animal experimental literature related to the treatment of HSP with TCM in the past decade were reviewed, and the effects of TCM in alleviating abnormal glycosylation of IgA1, regulating the immune imbalance of Th1/Th2 and Treg/Th17 cell, reducing circulating immune complex, and inhibiting inflammatory responses were compiled and summarized, In order to providing a reference for the further research on TCM for the treatment of HSP and inspiring new research ideas.