1.Chronic Disease Research Center, Medical College, Dalian University;2.Zhongshan Hospital Affiliated to Dalian University;3.College of Pharmacy, Yanbian University
The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)
炎症性肠病（inflammatory bowel disease, IBD）是一种全球性的特发性疾病，病变部位累及回肠、直肠、结肠。IBD在临床早期就开始出现症状，包括腹部不适、腹泻、便血、发热、乏力和体重减轻。IBD的诊断是通过相关的临床表现、内窥镜检查结果和病变组织标本的组织病理学特征进行综合评价。生物制剂、口服皮质类固醇、水杨酸盐和手术是IBD的主要常规治疗方法。近年来在阐明IBD的发病机理方面取得了相当大的进展，在临床实践中认为是遗传易感性、环境因素和肠道黏膜屏障之间的复杂相互作用，从而导致异常的氧化应激、自噬及黏膜免疫反应。本文对遗传与环境因素、肠黏膜屏障功能、氧化应激、自噬功能异常和适应性免疫反应各方面研究进展进行简要归纳和阐述，为进一步研发治疗手段及改善临床治疗效果提供依据。
Inflammatory bowel disease (IBD) is a global idiopathic disease, involving the ileum, rectum and colon. IBD begins to appear early in clinical symptoms, including abdominal discomfort, diarrhea, hematochezia, fever, fatigue and weight loss. The diagnosis of IBD is based on the comprehensive evaluation of relevant clinical manifestations, endoscopic examination results and histopathological characteristics of pathological tissue specimens. Biological agents, oral corticosteroids, salicylic acid and surgery are the main conventional treatments for IBD. In recent years, considerable progress has been made in elucidating the pathogenesis of IBD. In clinical practice, it is considered that the complex interaction between genetic susceptibility, environmental factors and intestinal mucosal barrier leads to abnormal oxidative stress, autophagy and mucosal immune response. This paper briefly summarizes and expounds the research progress of genetic and environmental factors, intestinal mucosal barrier function, oxidative stress, autophagy dysfunction and adaptive immune response, so as to provide basis for further research and development of treatment methods and improvement of clinical treatment effect.