Shandong University of Traditional Chinese Medicine
The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)
经前烦躁症（premenstrual dysphoric disorder，PMDD）是经前期综合征的一种亚型，该病症在育龄女性中具有高患病率，病症包含乳房胀痛、头痛等身体症状以及严重的焦虑、抑郁、易怒等情绪症。目前PMDD已危及全球女性患者的生命健康，在第五版国际精神障碍诊断与统计手册（The Diagnostic and Statistical Manual of Mental Disorder，Fifth edition ed. DSM-5）中将PMDD判定为抑郁症五种类型之一。目前PMDD的病理机制研究主要集中于激素及受体表达方面，这也是目前动物模型构建的理论基础。而动物模型是联系基础研究与临床研究非常重要的一环，造就能够模拟临床症状的动物模型对于疾病发病机制的探索以及对症药物的研发都至关重要。目前，多种PMDD动物模型虽已被用于实验研究，但仍存在许多局限性，这在一定程度上阻碍了PMDD深层机制的研究。为此本文旨在通过梳理目前已知PMDD的发病机制，探讨现有用于研究的PMDD动物模型，以期为PMDD相关机制研究及药物研发提供参考。
Premenstrual dysphoric disorder (PMDD) is a subtype of Premenstrual syndrome with high prevalence in women during their reproductive life. It includes physical symptoms such as breast tenderness, headache as well as serious emotional symptoms such as anxiety, depression and irritability. These symptoms are menstrual specific, they appear before menstruation and disappear within a week after it ends. PMDD threatens the health of female patients all over the world, In The Diagnostic and Statistical Manual of Mental Disorder(Fifth edition ed,DSM-5）, PMDD is identified as one of the five types of depression. At present, studies on the pathological mechanism of PMDD mainly focus on hormone and receptor expression, which is the theoretical basis of the animal model establishment, as well. Animal model that can model after clinical symptoms of human beings is a very important to connect basic research to clinical research, which is also crucial to explore the pathogenesis and develop appropriate drugs. Although many kinds of animal models of PMDD have been used in experimental studies, there are still many limitations, which resulting in a barrier to further investigation of PMDD. Therefore, this review arranged the known pathogenesis research of PMDD and discuss the existing animal models of PMDD, aims to provide reference for PMDD related mechanism research and drug development.