模式生物斑马鱼在神经退行性疾病中的研究进展
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广州中医药大学

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广东省普通高校重点实验室项目(No. 2019KSYS005),广东省科技计划国际科技合作项(No.2020A0505100052)


Research Progress on Model Organism Zebrafish in Neurodegenerative Diseases
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guangzhou universirty of chinese medicine

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Guangdong General University Key Laboratory Project(No. 2019KSYS005); Guangdong Province Science and Technology Plan International Cooperation Project (No.2020A0505100052).

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    摘要:

    神经退行性疾病(Neurodegenerative disease,NDD)是一类慢性、进行性发展的神经疾病,以特异性神经元的大量丢失为主要特征,主要包括阿尔茨海默病(Alzheimer's disease, AD)、帕金森氏病(Parkinson's disease, PD)、亨廷顿舞蹈病(Huntington’s disease, HD)及肌萎缩性脊髓侧索硬化症(Amyotrophic lateral sclerosis, ALS)等。虽然不同类型神经退行性疾病的病变部位和病因各不相同,但大脑特定区域的迟发性神经细胞退行性病变、神经元或突触丢失是它们的共同特征,因此统称为神经退行性疾病。由于神经退行性疾病的复杂性、多基因调控性,导致其病因和发病机制尚不明确,因此这类疾病的治疗举步维艰。近年来,斑马鱼(Zebrafish)作为一种新型的模式生物,因其神经传导系统、神经元和神经胶质细胞类型及疾病相关基因同源性与人类都十分相似,受到越来越多的关注。目前,斑马鱼已广泛应用于神经退行性疾病的研究,并在此领域研究中已取得一定的成果,提高了我们对神经退行性疾病的认识。本文通过查阅近几年国内外相关文献,综述斑马鱼作为模式生物近年来在神经退行性疾病研究中的研究进展。

    Abstract:

    Neurodegenerative disease (NDD)is a chronic and progressive neurological disease characterized by the loss of a large number of specific neurons. It mainly includes Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Although the lesions and etiologies of different types of neurodegenerative diseases are different, delayed neurodegenerative lesions and cell loss in specific brain areas are their common characteristics. For this reason, it is collectively referred to as neurodegenerative diseases. In recent years, zebrafish have attracted increasing attention from society as a new type of model organism. Although there are some differences between zebrafish and human central nervous systems, zebrafish neural conduction systems, neuronal and glial cell types, and disease-related gene homology are very similar to those of humans. Zebrafish has been widely used in the study of neurodegenerative diseases, and some achievements have been made in this field to improve our understanding of these diseases, but because of the complexity, multi-factors and multi-gene regulation of neurodegenerative diseases, the etiology and pathogenesis of zebrafish are not clear, so the treatment of this kind of disease has always been a difficult problem. By consulting relevant literature from home and abroad in recent years, this study reviews recent advances in neurodegenerative diseases using zebrafish as a model organism.

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  • 收稿日期:2022-12-06
  • 最后修改日期:2023-04-18
  • 录用日期:2023-09-14
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