河南中医药大学 中医药科学研究院,河南省中医方证信号传导重点实验室,郑州 450046
Henan Key Laboratory of Traditional Chinese Medicine (TCM) Syndrome and Prescription in Signaling, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
Cachexia is a syndrome of multifactorial metabolic disorders involving multiple organs and is a common fatal factor in patients with malignant tumors. The major clinical symptoms are muscle atrophy and loss, and their mechanism is associated with excessive protein degradation and synthesis disorders. In recent years, traditional Chinese medicine has made a significant advantage in the use of few side effects, multi-targets, and multi-channel intervention diseases. It has unique value in preventing and treating tumor disease and muscle atrophy. This review mainly discusses the effect of muscle protein degradation and synthesis mediated by various signals on tumor Cachexia muscle atrophy and the regulatory role of traditional Chinese medicine to provide a reference for the clinical application and research of traditional Chinese medicine in the treatment of tumor Cachexia muscle atrophy.
PENG Mengwei, LIU Yan, ZHANG Yan, HAO Linglun, CHEN Yulong, WU Yaosong.蛋白合成与降解信号参与肿瘤恶病质肌肉萎缩及中医药调节机制研究进展[J].中国比较医学杂志,2023,33(7):123~129.复制