实验动物屏障设施微生物污染防控管理要点
作者:
作者单位:

1.中山大学实验动物中心,广州 510006;2.广东至远生物医药科技有限公司,广州 510006

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R-33

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Operational management and prevention of contamination in barrier environment facilities of laboratory animals
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1. Laboratory Animal Center of Sun Yat-sen University, Guangdong 510006, China. 2. Guangdong Zhiyuan Biopharmaceutical Technology Co. , Ltd, Guangzhou 510006

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    摘要:

    实验动物屏障环境设施运行过程中的病原微生物污染严重影响研究人员和动物健康或导致生物安全事故,干扰实验结果或导致实验中断。然而,在其长期运行中杜绝污染并非易事,可因管理和操作细节的疏漏而发生。病原微生物污染是长期困扰实验动物管理者的难题。笔者从事实验动物屏障设施运行管理多年,深感细节管理在防止病原体微生物污染中的重要性,为此,根据多年的工作经验,结合设施布局、人员管理等细节问题,加以总结,以供同行探讨和借鉴。

    Abstract:

    Laboratory animal barrier contamination by pathogenic microorganisms during the operation of environmental facilities seriously affects research and animal health or leads to biosafety incidents, interference of experimental result, or interruption of experiments. However, elimination of contamination during their long-term operation is difficult ,and can occur due to careless management or operational details. Contamination by pathogenic microorganisms is a major problem for laboratory animal managers. After engaged in laboratory animal barrier facility management for many years, The author deeply felt the importance of details management to prevent infection by pathogenic microorganism. Therefore, summarized of the details problem combined facility layout with staff management based on years of working experience, which in order to be discussed and used for reference.

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张 薇,王牧孜,邓少嫦.实验动物屏障设施微生物污染防控管理要点[J].中国比较医学杂志,2023,33(7):117~122.

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  • 收稿日期:2022-08-11
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  • 在线发布日期: 2023-08-18
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