Hemorrhagic shock (HS) is one of the common causes of death, which is mostly due to trauma- induced fracture of limbs and rupture of vital organs, aneurysm rupture, and other causes of massive bleeding. The causes, triggers, and mechanisms of HS and establishment of animal models have been largely clarified, but animal models of HS combined with or complicated by other diseases need to be investigated further. Thus, we reviewed the current research status of the selection and application of various animals for HS models and their combination or complication with other disease models to provide researchers with a reference for the selection and application of HS-related models.