Mitochondrial dynamics include fusion and division. Dynamic-related protein 1 ( Drp1) is a key protein in mitochondrial division. The expression of Drp1 is increased during Parkinson’ s disease (PD), which leads to mitochondrial fragmentation and dysfunction and participates in the pathological process of PD. This paper reviews mitochondrial dynamics, Drp1 and their pathological relationships with the abnormal expression of α-synuclein, LRRK, PINK1 and Parkin in PD.