Duchenne muscular dystrophy ( DMD) is a fatal muscle disease caused by the loss of dystrophin protein, which is localized in the sarcolemma. Currently, DMD research concentrates on how to treat the disease, and the restoration of membrane function has become a promising therapeutic approach. This review focuses on the mechanism by which muscle membrane damage is caused by dystrophin abnormality and summarizes the research progress regarding membrane repair therapy toward its clinical application.