广东医科大学附属医院,广东 湛江 524001
Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
非肌肉肌球蛋白 IIA(non-muscle myosin IIA, NM IIA)由非肌肉肌球蛋白重链 9(Non-muscle myosin heavy chain 9, MYH9)基因编码,是非肌肉肌球蛋白 II 的家族成员,在多种细胞中表达,参与调控细胞收缩、细胞迁移和细胞形状维持等细胞生理过程。 NM IIA 对脑、肾、血管等发育至关重要,其基因突变导致 MYH9 相关疾病 (MYH9-related disease,MYH9-RD)。 此外,近年来有研究表明 NM IIA 还参与其他生理和病理过程的调节,如血管新生和肿瘤进展等。 本文将对人、小鼠和斑马鱼中 NM IIA 相关功能的研究进展进行综述。
The non-muscle myosin IIA (NM IIA), encoded by non-muscle myosin heavy chain 9 (MYH9), is a member of the non-muscle myosin II family. NM IIA is expressed in a variety of cell types and plays a critical role in cellular physiological processes, such as cell contraction, cell migration, and cell shape maintenance. NM IIA is essential for the development of the brain, kidney, vessels, and other organs. A mutation of NM IIA causes MYH9-related disease (MYH9-RD). Recently, it has been shown that NM IIA is also involved in the regulation of other physiological and pathological processes, such as angiogenesis and tumor progression. Here, we summarize the recent progress of research on NM IIA functions in humans, mice, and zebrafish.
黎国安,钟望涛,张晶晶.多物种中非肌肉肌球蛋白 IIA 相关功能的研究进展[J].中国比较医学杂志,2022,32(6):87~92.复制