Objective To observe the abortion model data of the CBA/ J and CBA/ Ola sub-strains of mice. The Embryo resorption rate of 10~ 16 weeks CBA/ J mice was 12. 8% ~ 22. 2% higher than 11. 4% ~ 13. 0% of 10 ~ 16 weeks CBA/ Ola mice. Methods Abortion model experiments on CBA/ J and CBA/ Ola mice were designed. Each murine subline was matched with six groups of animals and observed. Three of the six groups are 10-week-old female CBA groups and three are 16-week-old female CBA groups. Three groups for each week of age include the mutual mating of CBA, BALB/ c and CBA, DBA2 and CBA. Results CBA/ J mice have a higher Embryo resorption rate compared with CBA/ Ola mice, and the Embryo resorption rate of 16-week-old female CBA/ J mice is higher than the rate of 10-week-old female CBA/ J. Both the CBA/ J and CBA/ Ola murine sublines have embryo absorption problems in their mutual mating, the reasons for which need to be further studied. Conclusions 16-week-old CBA/ J female mice are more suitable for the establishment of abortion models.