大鼠腹膜粘连的模型构建与评价
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A review of the establishment and evaluation of rat model of peritoneal adhesions
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    摘要:

    腹膜粘连是腹部外科手术术后的常见并发症,可导致肠梗阻、慢性盆腹腔疼痛、不孕等,并可增加再入院率、再次手术的风险及经济负担。建立合适的腹膜粘连动物模型对于研究腹膜粘连及其并发症的发病机制、治疗和预防等具有重要的作用。粘连模型动物中以大鼠最为常用,根据腹膜粘连形成的不同因素,其造模的方式也多种多样,但目前尚无任何一种造模方式及评价方法可代表所有情况。本文对目前大鼠腹膜粘连模型常用的造模方式、评价方法作一综述。

    Abstract:

    Postoperative peritoneal adhesion is a common complication after laparotomy, resulting in complications such as intestinal obstruction, chronic abdominopelvic pain,and infertility in women, which may increase the rate of rehospitalization, risk of reoperation and economic burden. The establishment of appropriate animal models is essential for understanding the pathogenesis, therapy and prevention of peritoneal adhesions and their complications. Rat is the most widely used animal species for establishing models of peritoneal adhesions. According to the etiology of peritoneal adhesion, there are many different types of models. However, to date there has not been a universal way of model establishment and evaluation suitable for all types of peritoneal adhesions. Here in this review, we will summarize and discuss the commonly used methods of model establishment and evaluation of peritoneal adhesions in rats.

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郑培鸿,陈维荣.大鼠腹膜粘连的模型构建与评价[J].中国比较医学杂志,2017,27(9):104~110.

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  • 收稿日期:2017-01-16
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  • 在线发布日期: 2017-09-23
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